Fig. 2

Inflammatory time-course analysis of lipopolysaccharide (LPS)-induced mouse model of ALI. Mice were killed at various timepoints after intratracheal LPS. Plasma concentrations of A IL-1β and B IL-6 were variable after disease induction. C Lung vascular permeability as assessed by bronchoalveolar lavage fluid (BALF) protein concentration peaked at 24 to 72 h. Both BALF D cell concentration and E IL-1β levels were highest at 24 h after ALI induction, whereas F IL-6 levels peaked at 10 h. Data are presented as mean ± SEM, N = 3–4 per timepoint, *P < 0.05, **P < 0.01, ***P < 0.001