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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury

Fig. 5

Biodistribution analysis of MSC-EVs during LPS-induced ALI. A Study design in which DiR-labeled MSC-EVs were administered at 24 h after ALI induction, followed by fluorescence imaging at various times after EV delivery. B Representative live and ex vivo images are shown. C Comparison of radiant efficiency between the lungs, liver, spleen and kidneys. Distribution of MSC-EVs was greatest after 48 h, and lung fluorescence was threefold higher than the spleen/liver and 80-fold higher than the kidneys at peak fluorescence. N = 4–10 per group. Data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512