Table 3 Antioxidant drug pretreatment improves MSC survival

GSH

10 μM

Mouse adipose tissue

Reduced H₂O₂-induced injuries by reducing ROS generation and cell apoptosis

[56, 63]

Melatonin

10 μM

Mouse adipose tissue

Reduced H₂O₂-induced injuries by reducing ROS generation and cell apoptosis

[56, 63]

Edaravone

20 μM

Human umbilical cord

Reduced LPS/H₂O₂-induced injuries by improving cell viability and by reducing cell apoptosis

[56]

Zeaxanthin dipalmitate

0.5 μM

Human adipose tissue

Reduced LPS/H₂O₂-induced injuries by reducing ROS generation, cell apoptosis and inflammation

[67]

Ginsenoside Rg1

50 μM

Mouse bone marrow

Reduced cell senescence and improved antioxidant capacity of MSCs via NRF-2 and PI3K/Akt signaling

[120]

Wedelolactone

3.18–318 μM

Rat bone marrow

Reduced •OH- or O₂⁻-induced injuries by improving cell viability

[121]

Astaxanthin

16 μM

Human adipose tissue

Reduced H₂O₂-induced injuries by reducing ROS generation and cell apoptosis

[122]

Exendin-4

20 nM

Rat adipose tissue

Reduced H₂O₂-induced cell apoptosis via PI3K/Akt–Sfrp2 pathways

[123]

Taxifolin

1–100 μg/mL

Rat bone marrow

Reduced •OH -induced injuries by improving cell viability

[124]

Chlorogenic acid

100 μM

Rat bone marrow

Reduced H₂O₂-induced cell apoptosis via PI3K/AKT signal and FOXO family genes

[125]

Vitamin E

100 μM

Human umbilical cord

Enhanced MSC survival by reducing oxidative stress

[68]