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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome

Fig. 2

Generation and characterization of iPSC-CMs. A Typical morphology of skin fibroblasts from the healthy control subjects and the BrS patient. Scale bar, 400 μm. B Typical morphology of control and BrS iPSCs. Scale bar, 100 μm. C. Representative graphs of karyotypes of control and BrS iPSCs. D Representative graphs of ALP staining of control and BrS iPSCs. Scale bar, 100 μm. E Representative graphs of pluripotent staining of control and BrS iPSCs using SOX2 (green), NANOG (red), OCT4 (green) and SSEA4 (red). DAPI indicates nuclear staining (blue). Scale bar, 100 μm. F Confirmation of the existence of the SCN5A T1788fs mutation in BrS iPSCs (BrS C9 iPSC line) but not in control iPSCs (CON#1 iPSC line)

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Stem Cell Research & Therapy

ISSN: 1757-6512