Fig. 1

Single-cell RNA sequencing analysis of hASCs from non-diabetic (control) and diabetic (DM) patients. A Cell population distribution by t-SNE projections showed a similar pattern in control and DM individuals (left and middle, n = 8812 and 8689, respectively). Bar charts of 11 clusters identified from control and diabetic ASCs showed slight differences in the proportion of clusters (right). B Dot plot showed decreased expression of the several ECM organizing-related genes in hASCs from DM patients. C Dot plot showed variation in the relative expression of angiogenesis-related genes in hASCs from both groups. The sizes of the dots in (B) and (C) corresponded to the percentage of cells expressing the genes in each cluster, and the color scale represented the average expression level. hASC human adipose-derived stem cell, ECM extracellular matrix, t-SNE t-distributed stochastic neighbor embedding