Fig. 6

Histology of the healed wound tissue. A Representative images of H&E-stained wound sections at day 21. Red arrows indicated the wound margin. Scale bar = 500 µm. B Representative images of Masson’s trichrome-stained wound sections at day 21. The differences in the dermal matrix organization were examined under higher magnification, and wounds treated with dbLG exhibited significantly higher collagen density relative to those received PBS or dbHG. Scale bar = 500 µm; higher magnification scale bar = 100 µm. *p < 0.05 relative to PBS, ^#p < 0.05 between the indicated groups. dbASC murine ASCs from db/db mice, dbHG dbASCs cultured in HG condition, dbLG dbASCs cultured in LG condition, H&E hematoxylin and eosin