Fig. 5
From: Loss of Dip2b leads to abnormal neural differentiation from mESCs
Dip2b knockout affects ECM-receptor interaction and axon guidance in the KSR medium. A MA plot showing the expression of DEGs for KO versus WT at day 9 post differentiation. Upregulated and downregulated genes are plotted in red and blue, respectively. B and C KEGG pathway analysis of DEGs from KO versus WT at day 9 post differentiation. D and E GO analysis. Top ten GO terms of upregulated and downregulated DEGs from KO versus WT at day 9 post differentiation. F The GSEA showing the expression pattern of ECM-receptor interaction-related genes in KO and WT. G Heatmap showing the expression of DEGs in KO and WT. H Expression of upregulated and downregulated genes by qRT-PCR in WT and KO ESCs (n = 3). Values represent mean ± SEM (ns means not statistically significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)