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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes

Fig. 2

Whole mRNA-seq reveals the global impacts of SARS-CoV-2 viral genes on the transcriptome of hESC-CMs. A Scheme of whole mRNA-seq to study the global impacts of SARS-CoV-2 viral genes on the transcriptome of hESC-CMs. B–D Volcano blots showing differentially expressed genes caused by Nsp6OE (B), Nsp8OE (C), and MOE (D) in hESC-CMs. E–G Canonical signaling pathways (SP) analyses of the upregulated genes induced by Nsp6OE (E), Nsp8OE (F) and MOE (G) in hESC-CMs. H Summary of up- (red) or down-regulated (blue) DEGs by Nsp6OE, Nsp8OE and MOE in hESC-CMs. I–J Canonical signaling pathways of the genes that are differentially induced by Nsp6OE, Nsp8OE and MOE in hESC-CMs

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Stem Cell Research & Therapy

ISSN: 1757-6512