Fig. 3
Concordant transcriptomic analysis. A Volcano blots showing differentially expressed genes in hiPSC-CMs infected by SARS-CoV-2 virus versus Mock control [17]. B, C Comparison of DEGs between hESC-CMs (Nsp6OE, Nsp8OE and MOE vs. Control) and hiPSC-CMs (SARS-CoV-2 vs. Mock). A two-tailed unpaired t test was used to calculate p values. The remarkable p value indicates the significant overlap between two gene sets. D–F Heat map showing representative apoptotic genes in D, inflammation genes in E, and heart contraction genes in F among indicated functional groups. G Frequencies of DEGs that are up-regulated by Nsp6OE/Nsp8OE/MOE in DEGs that are up-regulated due to SARS-CoV-2 infection. H Frequencies of DEGs that are down-regulated by Nsp6OE/Nsp8OE/MOE in DEGs that are down-regulated due to SARS-CoV-2 infection. I GO analysis of DEGs solely up-regulated by SARS-CoV-2 infection. J GO analysis of DEGs solely down-regulated by SARS-CoV-2 infection