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Table 3 Detailed prescribed treatments before the receiving of AT-MSCs and at the last F/U visit

From: Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Pt. no

Hx of aGVHD

BoS therapies before AT-MSC

allo-HSCT-AT-MSC interval (mo)

Treatment(s) at the last F/U

F/U duration (mo)

CMV infection post-therapy

Status

1

No

PDN (20 mg/d), cyclosporine (75 mg/d), MMF (500 mg/d), and 14 ECP sessions

8

PDN (10 mg, two times per week), ruxolitinib (5 mg/d), and 8 ECP sessions

13

No

Alive

2

Grade III skin and GI

PDN (15 mg/d) and tacrolimus (0.5 mg/d)

18

Ruxolitinib (2 mg/d), tacrolimus (0.5 mg, two times per week), and 15 ECP sessions

20

No

Alive

3

Grade II skin

PDN (25 mg/d), tacrolimus (1 mg/d), and MMF (600 mg/d)

12

PDN (10 mg/d), MMF (250 mg/d), tacrolimus (0.5 mg/d), and 19 ECP sessions

19

No

Alive

4

No

PDN (15 mg/d), sirolimus (1 mg/d), and MMF (125 mg/d)

9

PDN (12.5 mg/d), ruxolitinib (5 mg/d), and 18 ECP sessions

19

No

Alive

  1. aGVHD acute graft-versus-host disease, allo-HSCT allogeneic hematopoietic stem-cell transplantation, AT-MSC adipose tissue-derived mesenchymal stem/stromal cells, BoS bronchiolitis obliterans syndrome, CMV cytomegalovirus, d day, ECP extracorporeal photopheresis, F/U follow-up, GI gastrointestinal, Hx history, mg milligrams, MMF mycophenolate mofetil, mo months, PDN prednisolone