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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4

Fig. 7

Possible mechanism of the regulation of IL-2 signaling pathway via CIS and DUSP4 increased by the ADSC secretome. The ADSC secretome induces upregulation of CIS and DUSP4 in NK cells, leading to attenuated effector function of NK cells while maintaining cell proliferation. CIS binds to pJAK1 and pJAK3 and targets them to proteasomal degradation to suppress their enzymatic activity. DUSP4 dephosphorylates pSTAT5 and pAKT to weaken the amplitude of IL-2 signaling cascade

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Stem Cell Research & Therapy

ISSN: 1757-6512