Table 1 Comparative outcome analysis for different therapeutic approaches in rodent models of acute myocardial infarction
Therapeutic approach | Outcome heart function: LVEF | Outcome tissue remodeling: scar size | References | ||
|---|---|---|---|---|---|
Mean group differencea (MIN, MAX) [%] | Study number | Mean group differencea (MIN, MAX) [%] | Study number | ||
iCMP transplantation after ex vivo fibroblast reprogramming | 20 | 1 | − 23 | 1 | This study |
iCPC transplantation after ex vivo fibroblast reprogramming | 20 (6, 30) | 3 | − 13 (− 5, − 20) | 2 | Reviewed in [13] |
Endogenous CPC transplantation after ex vivo expansion | 12 (0.3, 26) | 70 | − 8 (− 0.8, − 34) | 23 | Reviewed in [58] |
In vivo reprogramming of infarct fibroblasts into iCMs | 11 (4, 27) | 7 | − 19 (− 5, − 40) | 7 | Reviewed in [13] |