Fig. 1
From: Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics
Risk factors that contribute to PF and MMT. Many factors cause MMT, including infectious peritonitis, bioincompatibility of PDS, sterile inflammation and biomechanical injury. PDS peritoneal dialysis solution, MMT mesothelial–mesenchymal transition, MCs mesothelial cells, BM basement membrane, ECM extracellular matrix, ZO-1 zonula occludens-1, α-SMA α-smooth muscle actin. Created with BioRender.com