Fig. 7

Histopathological examination of knee joint A Histopathology: representative knee joint sections of each group at day 52 or 53 after administration of primary immunization. Original magnification: ×100, arrowhead: severe cartilage destruction. B Score of cartilage damage; 0–4 (no damage to severe damage). Data obtained from experimental groups were compared using one-way analysis of variance followed by Tukey’s multiple comparison post-hoc tests (n = 10/group).*, Significant differences (p < 0.05) from the control (C group)