Fig. 6

Central Illustration: transcatheter implantation of ACP-01 for cardiomyopathy. Autologous multipotent hematopoietic cells obtained by a blood draw undergo a process of trans-differentiation to ACP-01 a which are programmed to form tubular, endothelial cells (b). Cells undergo transcatheter, intramyocardial, or intracoronary implantation of ACP-01 (c). Cytokine expression of CXCL8, VEGF, and angiogenin (d) promotes angiogenesis (e). Small black arrows indicate neo-angiogenesis (photomicrograph X400). The expression of CXCL8 (f) enhances cell migration and cell implantation (g). Injured myocardium expresses CXCL12 ligand (f) which attracts the CXCR 4 receptors on ACP-01, enhancing migration (g) to the ischemic or non-ischemic dilated myocardium (photomicrograph X400). Elevated CXCL8/CXCR1,2 axis (h) expressed by ACP-01 repress apoptosis through upregulation of the NF-kB axis (i). These function collectively to improve LVEF