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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

Fig. 2

hiPSCs display classical pluripotent stem cell morphology and positively express core pluripotency transcription factors. Phase contrast images of healthy control a BJ-hiPSC and diseased b–e SBG1, 2, 3, 5 hiPSCs show the presence of pluripotent stem cell morphology with cells exhibiting high nuclear-cytoplasmic ratio and large nucleoli, representative of actively dividing undifferentiated cells. Healthy control BJ-hiPSC (f, k) and diseased SBG1-hiPSC (g, l), SBG2-hiPSC (h,m), SBG3-hiPSC (i, n) and SBG5-hiPSC j, o are positive for POU5F1 (f–j) and SOX2 (k–o pluripotent markers. Image inserts contain corresponding DAPI nuclear counterstain. DAPI, 4’,6-diamidino-2-phenylindole. Scale bar = 100 µm

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Stem Cell Research & Therapy

ISSN: 1757-6512