Fig. 5

Mitochondrial respiratory profile of hiPSC cell lines. a Scheme of expected oxygen consumption rate (OCR) under basal conditions, b OCR profile of BJ-iPSC and diseased (SBG1, 2, 3, 5) hiPSCs, c basal respiration, d proton leak, e maximal respiration, f mito-ATP production after oligomycin injection g spare respiratory capacity after FCCP injection, h non-mitochondrial respiration after Rot/AA injection, i coupling efficiency. All parameters are in pmol/min/1000 cells. Data are presented as mean ± SD. Experiments were repeated at least three times on different days under the same conditions. *p < 0.05**p < 0.01***p < 0.001****p < 0.00001. Comparative analyses for all diseased (SBG1, 2, 3, 5) hiPSCs were conducted with the healthy control BJ-hiPSC line