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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

Fig. 7

LS-hiPSC cells differentiation into neurons. a Representative phase contrast images for SBG2-hiPSCs on day 0 of differentiation using medium 1-E6 and medium 2-E6 + BMPi. On day 10 of differentiation using Medium 2-E6 + BMPi, rosettes were generated. Day 20 of differentiation using medium 1-E6, SBG2-hiPSCs had formed a larger colony of neural rosettes. While using medium 2-E6 + BMP, SBG2-hiPSCs exhibited neural projections from the larger cell colonies. b A bar graph showing that Medium 2 (E6 + BMPi) led to a significant increase in the average number of rosettes for SBG1 and SBG3 compared to Medium 1-E6 after 20 days. c Bar graph of the average time for neural rosettes to appear for Medium 1 (E6) was greater than Medium 2 (E6 + BMPi). *p < 0.05**p < 0.01***p < 0.001****p < 0.00001

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Stem Cell Research & Therapy

ISSN: 1757-6512