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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis

Fig. 8

Possible mechanism of sFgl2 gene-modified MSCs in the treatment of experimental AIH mice. sFgl2 gene-modified MSCs may promote the differentiation of CD4+ T cells into Tregs and inhibit their differentiation into Th17 and Th1 cells by activating SHP2 and SMAD2/3 to treat experimental AIH mice more effectively. AIH: autoimmune hepatitis; MSCs: mesenchymal stem cells; sFgl2: soluble fibronectin-like protein 2; sFgl2-MSCs: sFgl2 gene-modified MSCs; Tregs: T regulatory cells. This image was drawn by the author using Adobe Illustrator 2023

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Stem Cell Research & Therapy

ISSN: 1757-6512