Table 4 Disease-gene associations significantly enriched in the proteins functional network (Fig. 4) of the 157 hAMSC secretome pools 1–4 common proteins

DOID:7

Disease of anatomical entity

8.22E-07

VCL,LGALS1,MYH9,MMP2,LAMB1,SERPINE1,COL1A1,GAPDH,TPI1,SPARC,CTSD,C3,KRT9,KRT1,ACTN4,CHI3L1,LAMC1,LTBP2,YWHAE,VCAN,KRT10,PLOD2,UCHL1,CALM3,COL6A3,ALB,COL1A2,PPIB,COL3A1,YWHAG,EEF2,EFEMP2,KRT2,CALR,COL12A1,FBN1,MDH2,FLNC,P4HB,PAPPA,TPM4,CTSB,FN1,ACTB,VCP,COL4A2,PNP,KRT19,COL6A1,THBS2,TAGLN2,LMNA,FLNA,COL5A1,SPTAN1,PGK1,HSPG2,HSPA1B,PSAP,ALDOA,YWHAZ,C1S,GPI,TGFBI,PARK7,FLNB,HARS,SERPINH1,MDH1,C1R,KRT8,PRKCSH

DOID:13,359

Ehlers-Danlos syndrome

6.75E-06

COL1A1,COL1A2,COL3A1,COL12A1,COL5A1,C1S,C1R

DOID:65

Connective tissue disease

6.78E-06

MMP2,COL1A1,SPARC,PLOD2,COL6A3,COL1A2,PPIB,COL3A1,EFEMP2,COL12A1,FBN1,P4HB,VCP,COL6A1,THBS2,LMNA,FLNA,COL5A1,HSPG2,HSPA1B,C1S,FLNB,SERPINH1,C1R

DOID:12,347

Osteogenesis imperfecta

1.30E-05

COL1A1,SPARC,PLOD2,COL1A2,PPIB,P4HB,SERPINH1

DOID:4

Disease

1.69E-05

VCL,LGALS1,MYH9,PSMA3,MMP2,LAMB1,SERPINE1,COL1A1,GAPDH,TPI1,SPARC,CTSD,C3,KRT9,KRT1,ACTN4,CHI3L1,LAMC1,LTBP2,YWHAE,VCAN,KRT10,PLOD2,UCHL1,CALM3,COL6A3,ALB,COL1A2,PPIB,COL3A1,GAA,YWHAG,EEF2,EFEMP2,KRT2,CALR,COL12A1,FBN1,MDH2,FLNC,P4HB,PAPPA,UGP2,TPM4,CTSB,FN1,ACTB,VCP,COL4A2,PNP,KRT19,COL6A1,THBS2,TAGLN2,LMNA,FLNA,COL5A1,SPTAN1,PGK1,GSN,HSPG2,HSPA1B,IGFBP3,PSAP,ALDOA,YWHAZ,C1S,TKT,GDI1,GPI,TGFBI,PARK7,FLNB,HARS,SERPINH1,MDH1,CALU,C1R,LDHA,KRT8,PRKCSH

DOID:2256

Osteochondrodysplasia

2.23E-05

COL1A1,SPARC,PLOD2,COL1A2,PPIB,FBN1,P4HB,HSPG2,FLNB,SERPINH1

DOID:17

Musculoskeletal system disease

8.88E-05

MMP2,COL1A1,SPARC,PLOD2,COL6A3,COL1A2,PPIB,COL3A1,EFEMP2,COL12A1,FBN1,FLNC,P4HB,ACTB,VCP,COL6A1,THBS2,LMNA,FLNA,COL5A1,HSPG2,HSPA1B,C1S,FLNB,HARS,SERPINH1,C1R

DOID:9120

Amyloidosis

9.57E-05

C3,KRT1,ALB,FN1,ACTB,GSN,HSPG2,TGFBI

DOID:4603

Epidermolytic hyperkeratosis

0.00012

KRT9,KRT1,KRT10,KRT2

DOID:0050736

Autosomal dominant disease

0.0003

MYH9,COL1A1,C3,KRT1,ACTN4,YWHAE,KRT10,CALM3,COL6A3,COL1A2,COL3A1,EEF2,KRT2,CALR,FBN1,FLNC,UGP2,VCP,COL4A2,COL6A1,LMNA,FLNA,GSN,HSPG2,TGFBI,FLNB,PRKCSH

DOID:0080006

Bone development disease

0.00091

COL1A1,SPARC,PLOD2,COL1A2,PPIB,FBN1,P4HB,FLNA,HSPG2,FLNB,SERPINH1

DOID:0080001

Bone disease

0.0022

MMP2,COL1A1,SPARC,PLOD2,COL6A3,COL1A2,PPIB,FBN1,P4HB,VCP,COL6A1,THBS2,FLNA,HSPG2,FLNB,SERPINH1

DOID:0060877

Bullous congenital ichthyosiform erythroderma

0.003

KRT1,KRT10,KRT2

DOID:0060158

Acquired metabolic disease

0.0042

TPI1,C3,KRT1,ALB,FN1,ACTB,COL6A1,PGK1,GSN,HSPG2,TKT,TGFBI

DOID:14,330

Parkinsons disease

0.0212

YWHAE,UCHL1,YWHAG,YWHAZ,PARK7

DOID:174

Acanthoma

0.0212

KRT1,KRT10,KRT2

DOID:863

Nervous system disease

0.0212

MYH9,LAMB1,COL1A1,GAPDH,CTSD,C3,LAMC1,LTBP2,YWHAE,VCAN,UCHL1,COL6A3,ALB,YWHAG,EEF2,FBN1,MDH2,CTSB,FN1,ACTB,VCP,COL4A2,LMNA,FLNA,COL5A1,SPTAN1,HSPG2,PSAP,YWHAZ,TGFBI,PARK7,HARS,MDH1,KRT8

DOID:0050739

Autosomal genetic disease

0.0378

MYH9,PSMA3,COL1A1,C3,KRT1,ACTN4,YWHAE,KRT10,CALM3,COL6A3,COL1A2,PPIB,COL3A1,EEF2,EFEMP2,KRT2,CALR,FBN1,FLNC,UGP2,VCP,COL4A2,PNP,COL6A1,LMNA,FLNA,GSN,HSPG2,IGFBP3,PSAP,TGFBI,PARK7,FLNB,HARS,PRKCSH

DOID:0050557

Congenital muscular dystrophy

0.0459

COL6A3,COL12A1,COL6A1,LMNA

DOID:630

Genetic disease

0.0488

MYH9,PSMA3,COL1A1,GAPDH,CTSD,C3,KRT1,ACTN4,LTBP2,YWHAE,VCAN,KRT10,CALM3,COL6A3,COL1A2,PPIB,COL3A1,EEF2,EFEMP2,KRT2,CALR,FBN1,FLNC,PAPPA,UGP2,VCP,COL4A2,PNP,COL6A1,LMNA,FLNA,PGK1,GSN,HSPG2,IGFBP3,PSAP,TGFBI,PARK7,FLNB,HARS,PRKCSH

DOID:90

Degenerative disc disease

0.0488

MMP2, COL1A1,THBS2