Fig. 5

hMSCs RNA sequencing revealed the differential RNA expression in hAD-MSCs and hUC-MSCs A Hierarchical clustering of differentially expressed genes in hAD-MSCs and hUC-MSCs group (n = 5/group). B Volcanic map shows the distribution of differentially expressed genes. The red and green dots indicate significantly upregulated in hAD-MSCs (1298) and hUC-MSCs (1077), respectively (FDR < 0.01 with more than twofold changes). FAS, VEGF-A and VEGF-C were pointed by black lines. C Venn diagram indicated the number of genes shared in hAD-MSCs and hUC-MSCs groups. D Normalized read counts of TSP-1, VEGF-A, VEGF-C and FAS in hAD-MSCs and hUC-MSCs group (n = 5). Bars represent mean ± SD. *P < 0.05; **P < 0.01; ns not significant. E Top 20 of KEGG pathway enrichment. The circle size represents the number of genes enriched in each indicated pathway. The color of the circle presents the significant Q value (corrected P value). A lower Q value indicates greater pathway enrichment. The Q value of each pathway is in the order of decreasing from upper to lower. FAS related pathway “TNF signaling pathway” were circled by red box