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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Systemically delivered adipose stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome by immunomodulating the inflammatory response through a CD11b+ cell-dependent mechanism

Fig. 5

Recruitment and maturation of leucocytes in irradiated KO CX3CR1 mice after SVF treatment. A Percentage of neutrophil (CD11b+Ly6G+) population B Percentage of CD11b+Ly6C+CCR2+, CD11b+Ly6C+MCHII− CX3Cr1− (P1), CD11b+Ly6C−MCHII+CX3Cr1int (P2), CD11b+Ly6C−MCHII+CX3Cr1+ (P3) and CD11b+Ly6C−MCHII+ F4/80+ among CD45+ cells from ileal lamina propria of WT and KO CX3CR1 control and at day 7 post-irradiation with or without SVF treatment in KO CX3CR1 mice (for each groups n = 6). C Representative immuno co-staining F4/80 (red), CX3CR1-GFP (green) in the ileum at day 7 post-irradiation with or without SVF treatment in KO CX3CR1. Dapi stained nuclei (blue). Scale bar: 50 µm. The data are represented by mean ± SEM (for each groups n = 4–5). P values were calculated by ANOVA with Tukey correction; *p < 0.01; **p < 0.001 compared with the KO CX3CR1 control group; #p < 0.01; ##p < 0.001 compared with the KO CX3CR1 irradiated group; $p < 0.01; $$p < 0.001 compared with the WT control group

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