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Fig. 12 | Stem Cell Research & Therapy

Fig. 12

From: Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing

Fig. 12

Real-time PCR analysis of HIF-1α, VEGF-A, and TGF-β1 (a–c, respectively) in normoxic and hypoxic conditions. a The HIF-1α expression level was significantly higher in the cells exposed to CoCl2 (H-CA group) compared to the N-CA group. b The expression level of VEGF-A was high in the H-CA group compared to other groups. In the presence of TP, compared to the H-CA, H-CA/AA, and H-CA/AA/TP groups, the expression of VEGF-A decreased. c) The expression of TGF-β1 had a high level of expression in all groups compared to the N-CA group, and in the H-CA group was higher than other groups (**p < .01)

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Stem Cell Research & Therapy

ISSN: 1757-6512