Table 1 Inclusion and exclusion criteria used to select participants for the clinical trial

Written informed consent

Positive history of hydrosalpinx or anatomical uterine disorders (In vaginal sonography or HSG)

Age between 25 and 45 years

Severe male factor infertility of their husbands (count < 15 million/ml)

Serum AMH < 1.1 ng/ml (at the screening visit and in the absence of OC or sex-steroid intake)

Antral follicular count (AFC) in both ovaries < 4 (at screening visit and in the absence of OC or sex-steroid intake)

Positive history of at least1 standard previous IVF-ET or ICSI-ET

Normal thyroid hormones (TSH and FT4)

Normal level of prolactin

Normal level of fasting blood sugar

Normal Liver tests (SGOT, SGPT)

Normal level of BUN, creatinine

Negative Infectious tests (HIV, HCV, HBS Ag, VDRL)

Normal coagulation factors (PT, PTT, BT)

Normal serum levels of sodium, potassium, calcium, phosphorus

Negative history of endometrioma or other ovarian cysts

Negative history of previous ovarian surgery

Negative history of cancer

Negative history of a known autoimmune disorder