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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma

Fig. 2

Impact of TF inhibition on the coagulant activity of UC- and DP-MSCs. a and b UC-MSCs (a) and DP-MSCs (b) were incubated with an anti-TF inhibitory monoclonal antibody (clone HTF-1) or an isotype control antibody (clone MOPC-21) and analyzed using a colorimetric FXa quantification assay. The HTF-1 antibody was capable of suppressing active TF. c and d The coagulant activity of UC-MSCs (c) and DP-MSCs (d) was significantly reduced in the presence of the HTF-1 antibody compared to the isotype control, but it was higher than that of the NaCl negative control samples

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Stem Cell Research & Therapy

ISSN: 1757-6512