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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma

Fig. 5

Impact of environmental factors on TF expression in UC- and DP-MSCs. a, b Culture of UC-MSCs (a) and DP-MSCs (b) in 2% oxygen conditions (hypoxia) upregulated TF expression compared to an ambient oxygen concentration of 21% (normoxia). c The inflammatory cytokines IFNγ and TNFα did not change TF levels in UC-MSCs. d On the other hand, TF levels were enhanced in DP-MSCs in the presence of TNFα but not IFNγ. e The coagulant activity of UC-MSCs did not change upon TNFα treatment. f The coagulant activity of DP-MSCs was higher upon TNFα treatment

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Stem Cell Research & Therapy

ISSN: 1757-6512