Fig. 1From: The nuclei of human adult stem cells can move within the cell and generate cellular protrusions to contact other cellsNuclear movement generated cellular protrusions that appeared and disappeared from the surface of hBM-MSC-derived intermediate cells. A Time-lapse imaging showed that when hBM-MSCs were exposed to neural induction medium, they rapidly reshaped from a flat to a spherical morphology. Subsequently, we observed hBM-MSC-derived intermediate cells (white asterisk) in which nuclear movements generate only one cell protrusion (white arrow) and hBM-MSC-derived intermediate cells (yellow asterisk) in which nuclear movements alternately generate one or two cellular protrusions (yellow arrows). B We found that when an hBM-MSC-derived intermediate cell has a nucleus without lobes, its movement within the cell generates only one cell protrusion (yellow arrow). C However, if the hBM-MSC-derived intermediate cell has a lobed nucleus, it will generate one or two cellular protrusions depending on how it moves within the cell (yellow arrows). Scale bar: 10 μm. PhC: Phase-contrast photomicrographs. The number at the top indicates the time since the time-lapse image began. Elapsed time is displayed in the format (hours:minutes)Back to article page