Outcomes | Multivariate analysis |
|---|
Hazard ratio (95%CI) | P-value |
|---|
Relapse† |
HID | reference | |
MSD | 0.482 (0.158,1.473) | P = 0.200 |
MUD | 0.654 (0.216,1.983) | P = 0.450 |
TRM* |
HID | reference | |
MSD | 1.207 (0.529,2.750) | P = 0.660 |
MUD | 0.414 (0.121,1.420) | P = 0.160 |
RFS‡ |
HID | reference | |
MSD | 0.747 (0.385,1.450) | P = 0.388 |
MUD | 0.550 (0.247,1.224) | P = 0.143 |
OS§ |
HID | reference | |
MSD | 0.863 (0.423,1.726) | P = 0.686 |
MUD | 0.133 (0.192,1.243) | P = 0.133 |
GRFS* |
HID | reference | |
MSD | 1.609 (1.015,2.551) | P = 0.043* |
MUD | 0.471 (0.242,0.916) | P = 0.026* |
- †Relapse Adjusted for diagnosis (MDS: HR = 0.443, 95%CI, 0.208–0.946; P = 0.035), cytogenetic risk (Adverse risk: HR = 2.518, 95%CI, 1.361–4.658; P = 0.003), CR1 (Non-CR1: HR = 2.486, 95%CI, 1.307–4.729; P = 0.005)
- *Transplant-related mortality (TRM) adjusted for age (over 60: HR = 1.548, 95%CI, 0.820–2.920; P = 0.180), HCT-CI (2 ~ 3: HR = 2.604, 95%CI, 1.301–5.210; P = 0.007. 4 ~ 6: HR = 5.060, 95%CI, 1.770–14.470; P = 0.002), TCI (over 4: HR = 0.598, 95%CI, 0.318–1.120; P = 0.110), refractory or relapsed disease status (R/R: HR = 1.582, 95%CI, 0.779–3.210; P = 0.200), and ABO blood type (Not matched: HR = 1.496, 95%CI, 0.813–2.750; P = 0.200)
- ‡Relapse-free survival (RFS) adjusted for HCT-CI (2 ~ 3: HR = 1.605, 95%CI, 0.951–2.712; P = 0.077. 4 ~ 6: HR = 3.609, 95%CI, 1.697–7.679; P < 0.001), TCI (Over 4: HR = 0.653, 95%CI, 0.406–1.048; P = 0.078), cytogenetic risk (Adverse risk: HR = 1.860, 95%CI, 1.161–2.979; P = 0.010), CR1 (Non-CR1: HR = 1.952, 95%CI, 1.194–3.191; P = 0.008)
- §Overall survival (OS) adjusted for age (Over 60: HR = 1.762, 95%CI, 1.012–2.929; P = 0.043), diagnosis (MDS: HR = 1.722, 95%CI, 1.032–2.929; P = 0.045), HCT-CI (2 ~ 3: HR = 2.201, 95%CI, 1.235–3.923; P = 0.007. 4 ~ 6: HR = 3.225, 95%CI, 1.361–7.643; P = 0.008), cytogenetic risk (Adverse risk: HR = 1.603, 95%CI, 0.922–2.789; P = 0.095)
- *GvHD, relapse-free survival (GRFS) adjusted for HCT-CI (2 ~ 3: HR = 1.786, 95%CI, 1.176–2.713; P = 0.007. 4 ~ 6: HR = 2.649, 95%CI, 1.421–4.937; P = 0.002), TCI (Over 4: HR = 0.663, 95%CI, 0.451–0.975; P = 0.036), CR1 (Non-CR1: HR = 1.952, 95%CI, 1.194–3.191; P = 0.008)
- *Significant at P < 0.05
