Fig. 2

NOD1 knockout protects against diabetes-induced alterations in retinal morphology and electrical response. A Representative OCT images of retinal cross-sections. The distinct color lines indicate four measurements obtained at intervals of 150 and 300 µm from the optic disc. B Distinct intraretinal layers displayed by OCT. C–E Quantification of total retinal thickness, IRL and ORL by OCT (n = 16 per group). F Representative images of dark-adapted 3.0 ERG. G, I Amplitudes and implicit time of scotopic a-waves indicating electrical responses of rod photocurrents measured by ERG. H, J Amplitudes and implicit time of scotopic b-waves showing electrical signals of depolarizing bipolar cells and Müller cells measured by ERG (n = 16 per group). The results are presented as the mean ± SD; ^#p < 0.05 compared with WT; ^§p < 0.05 compared with Akita; **p < 0.01. WT, wild type; OCT, optical coherence tomography; ERG, electroretinogram; GC/NFL, ganglion/nerve fiber layer; IPL, inner plexiform; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; ELM external limiting membrane;IS/OS, photoreceptor inner/outer segments; RPE, retinal pigment epithelium; C, cone; IRL, inner retinal layer; ORL, outer retinal layer