Skip to main content
Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells

Fig. 5

Mechanistic effects of GStemHep in APAP-ALF NOD/SCID mice. After APAP intoxication, mice were treated (APAP + GStemHep) or not (APAP only) with 1 × 106 thawed GStemHep. Mouse livers were collected at 3 h, 6 h and 24 h post cell transplantation to analyze variations in gene expression. RT‒qPCR analysis of the expression of inflammation or regeneration markers (mIL1RN, mIL6, mCCL2, mTGFβ, mKi67 and mVEGFa) in the APAP only and APAP + GStemHep groups (n = 5 per group). The results were normalized to the mGAPDH housekeeping gene and expressed as the fold change relative to healthy control mice (*p < 0.05; **p < 0.01; ns: not significant, Mann‒Whitney test)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512