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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells

Fig. 6

Mechanistic effects of GStemHep in APAP-ALF NOD/SCID mice. After APAP intoxication, mice were treated (APAP + GStemHep) or not (APAP only) with 1 × 106 thawed GStemHep. Mouse livers were collected at 6 h post cell transplantation to analyze variations in protein expression. A Proteome-wide data set variance described by Principal Component Analysis (PCA) on healthy (no APAP, n = 3), APAP only (n = 4) and APAP + GStemHep groups (n = 5), 6 h after cell transplantation (i.e., 9 h post-APAP intoxication). B KEGG pathway analysis of differentially regulated (up- and downregulated) proteins in the APAP + GStemHep group compared to the APAP group. (I) Upregulation pathways in pink. (II) Downregulation pathways in yellow. C Heatmap visualizing the intensities of differentially regulated proteins in three GO annotations (blood coagulation, complement activation and metabolic process) between all groups; each line represents a protein

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Stem Cell Research & Therapy

ISSN: 1757-6512