Fig. 5
Administration of iMSCACVR2B-Fc slightly inhibited recurrent HO in the surgical mouse model of FOP. A Schematic view of the experiments. CTX was injected on day 7. Primary HO was surgically removed on day 21. Cells (3 × 106) were administrated on days 22, 26, and 30. B Body weight monitoring. C Representative X-ray and μCT images of each group. μCT images were from pre- and post-surgery and on day 35. Arrowheads indicate primary HO, and arrows indicate recurrent HO. Scale bar, 10 mm. D Quantification of primary, post-resected, and recurrent HO. E BMC of HO sites. F Endurance tests were conducted using a rodent treadmill. G The mice’s exercise capacities were analyzed using the rotarod test. H, I Serum Fc fragment and Activin-A levels were detected by ELISA. Results represent the mean ± SEM. P > 0.05 by one-way ANOVA with Tukey’s multiple comparison test