Fig. 6
From: Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model
Transcriptome changes in mouse ovaries after MSC transplantation. A The number of upregulated genes in each group after MSC transplantation. Among them, 34 genes were shared among the groups. B Bar graph of the top 12 enriched terms across the 34 shared genes, coloured by p values. Network of enriched terms (left) coloured by cluster ID, where nodes that share the same cluster ID are typically close to each other. C Relative expression levels of Map4k1, a key gene in the MAPK pathway, in each group. The error bars indicate SD. *p < 0.05. D Protein‒protein interaction network and MCODE components identified through analysis of the 34 shared genes. E Heatmap of DEGs in each group. F Bubble graphs of enriched terms across unique up-regulated genes in each group. Old-UC-MSC-W1 versus old-saline-W1 (top left, 337 genes), old-AD-MSC-W3 versus old-saline-W3 (bottom left, 473 genes), old-UC-MSC-W3 versus old-saline-W3 (top right, 135 genes), old-AD-MSC-W1 versus old-saline-W1 (bottom right, 145 genes)