The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles

Table 1 Therapeutic effects and mechanisms of MSCs on POI in different models

Type of MSCs	Model	Route of administration	Outcome	Mechanism	References
hUMSCs	CDDP	Tail vein injection	Ovarian fibrosis↓	TGF-β1/Smad3	[24]
	CDDP	Tail vein injection	Theca-interstitial cells apoptosis ↓ Oxidative stress ↓	AMPK/mTOR pathway	[25]
	CDDP	Tail vein injection	Ovarian fibrosis ↓	AMPK/NR4A1 pathway	[26]
	CTX and BUS	Tail vein injection	Ovarian metabolome ↑	PI3K pathway	[27]
	CTX and BUS	Tail vein injection	GCs apoptosis ↓ Inflammation ↓	P38 and AKT pathway	[28]
hAMSCs	CTX	Tail vein injection	GCs apoptosis ↓ Angiogenesis ↑	Bax, Bcl2 and VEGF	[29]
	CTX	Tail vein injection	GCs apoptosis ↓ Angiogenesis ↑	SDF-1/CXCR4 axis; PI3K/Akt pathway	[30]
	10% hydrogen peroxide	Intraperitoneal injection	Fertility ↑ Inflammatory cytokines ↓	–	[31]
mBMSCs	CTX	Situ ovarian injection	GCs apoptosis ↓	Overexpression of miR-21; PDCD4 and PTEN	[32]
mBMSCs	ϒ-radiation	Tail vein injection	Ovarian apoptosis ↓ Ovarian proliferation ↑	TGF-β, Wnt/β-Catenin and Hippo pathway	[33]
MenSCs	CDDP	Tail vein injection	GCs apoptosis ↓ Ovarian fibrosis ↓	Secret FGF2	[34]

ISSN: 1757-6512