The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles

Table 2 Therapeutic effects and mechanisms of MSCs-derived EVs on POI in different models

EVs cellular origin	Method	Route of administration	Outcome	Mechanism	References
hUMSCs	CDDP	Tail vein injection	GCs apoptosis ↓ angiogenesis ↑	miR-126-3p via PI3K/AKT/mTOR pathway	[35]
	CTX	Tail vein injection	Angiogenesis ↑	PI3K/AKT pathway	[36]
	CDDP	Tail vein injection	GCs apoptosis ↓	MicroRNA-22-3p via KLF6 and ATF4-ATF3-CHOP pathway	[37]
	CTX	Tail vein injection	GCs proliferation ↑ ROS accumulation ↓	MicroRNA-17-5p via SIRT7 pathway	[38]
	Aging mouse	Tail vein injection	Oocytes activation ↑ Fertility ↑	miR-146a-5p and miR-21-5p via PI3K/mTOR pathway	[39]
	CDDP	Tail vein injection	GCs apoptosis ↓	MicroRNA-29a via HMG-Box /Wnt/β-Catenin pathway	[40]
hADSCs	CTX	Tail vein injection	GCs proliferation ↑ GCs apoptosis ↓ GCs marker ↑	SMAD pathway	[41]
mBMSCs	CDDP	Tail vein injection	GCs apoptosis ↓	miR-644-5p via P53 pathway	[42]
hAMSCs	CTX	Tail vein injection	GCs proliferation ↑ GCs apoptosis ↓ ROS accumulation ↓	SIRT4 pathway	[43]
hAFSCs	CTX	Tail vein injection	GCs apoptosis ↓	miR-369-3p via YAF2/PDCD5/p53 pathway	[44]
iPSC-MSC	CTX	Tail vein injection	GCs proliferation ↑ GCs apoptosis ↓	ILK-PI3K/AKT pathway	[45]

ISSN: 1757-6512