Table 3 Clinical trials related MSCs and MSCs-derived EVs therapy performed or underway for POI
Trial ID | Enrollment | Study Status | Interventions | Phases | Start Date | Locations | Out come of Trial |
|---|---|---|---|---|---|---|---|
NCT02151890 | 10 | Completed | Laparoscopic stem cells transplantation | Phase1|Phase2 | 2012/3/1 | Al Azhar University, Egypt | No results posted |
NCT01742533 | 40 | Unknown | hUMSCs, hCBMNCs transplantation combined HRT | Phase1|Phase2 | 2012/3/1 | Shenzhen People's Hospital, China | No results posted |
NCT02062931 | 60 | Unknown | Laparoscopic autologous BMSCs transplantation | Phase1|Phase2 | 2012/3/1 | Al Azhar University, Egypt | No results posted |
NCT02372474 | 112 | Completed | Laparoscopic autologous BMSCs transplantation | Phase1|Phase2 | 2012/3/1 | Al Azhar University, Egypt | No results posted |
NCT01853501 | 4 | Unknown | Autologous ADSCs ovary injection | Phase4 | 2012/9/1 | The affiliated Drum Towel Hospital, China | No results posted |
NCT02043743 | 60 | Unknown | Autologous BMSCs ovary injection | Phase1|Phase2 | 2014/1/1 | El-Rayadh Fertility Center, Egypt | No results posted |
NCT03069209 | 50 | Unknown | Autologous BMSCs ovary injection | Phase1|Phase2 | 2015/1/1 | Stem Cells Arabia, Jordan | No results posted |
NCT02151890 | 10 | Completed | Laparoscopic stem cells transplantation | Phase1|Phase2 | 2012/3/1 | Al Azhar University, Egypt | No results posted |
NCT02603744 | 9 | Unknown | Autologous ADSCs ovary injection | Phase1|Phase2 | 2015/6/1 | Royan Institute, Iran | No results posted |
NCT02644447 | 23 | Completed | hUMSCs with injectable collagen scaffold transplantation | Phase1|Phase2 | 2015/10/1 | The affiliated Drum Towel Hospital, China | No results posted |
NCT03033277 | 320 | Unknown | Intraovarian injection of hUMSCs under the guidance of ultrasonic | Phase1|Phase2 | 2016/2/1 | Institute of Zoology, Chinese Academy of Sciences, China | No results posted |
NCT02696889 | 3 | Completed | Laparoscopic autologous BMSCs ovary injection | NA | 2016/2/6 | University of Illinois at Chicago, United States | No results posted |
NCT02779374 | 10 | Terminated | Autologous BMSCs intravenous injection | NA | 2016/7/1 | South Valley University, Egypt | No results posted |
NCT03816852 | 12 | Suspended | hUMSCs intravenous injection | Phase2 | 2018/10/1 | Henan Provincial People's Hospital, China | No results posted |
NCT05138367 | 20 | Completed | UCA-PSCs or WJ-MSCs ovary injection under the guidance of ultrasonic | Phase1 | 2018/12/1 | The affiliated Drum Towel Hospital, China | No results posted |
NCT03877471 | 28 | Unknown | hESC-MSCs ovary injection under the guidance of ultrasonic | Phase1 | 2019/4/3 | The First Affiliated Hospital of Zhengzhou University, China | No results posted |
NCT05308342 | 66 | Recruiting | hUMSCs ovary injection under the guidance of ultrasonic | NA | 2019/11/20 | The affiliated Drum Towel Hospital, China | No results posted |
NCT05494723 | 6 | Not yet recruiting | YB-1113 (hUMSCs) intravenous injection | Phase1 | 2024/1/9 | Bright Cell, Inc | No results posted |
NCT06132542 | 10 | Not yet recruiting | ADSCs ovary injection under the guidance of ultrasonic | Phase1 | 2024/1/15 | Mongolian National University of Medical Science, Mongolia | No results posted |
NCT06202547 | 10 | Recruiting | BMSCs derived EVs ovary injection under the guidance of ultrasonic | Phase1|Phase2 | 2023/2/20 | Royan Institute, Iran | No results posted |
NCT06072794 | 9 | Recruiting | VL-PX10 (hPMSCs derived exosmes) intravenous injection | Phase1 | 2023/10/6 | Optimal Health Associates, United States | No results posted |