Fig. 4
From: Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
Effect of intranasal administration of GABA-loaded EVs on the number of seizures and time spent in seizures. 4 A: The total number of seizures per 10 h and the number of stage III, IV and V seizures per 10 h in a group of REs were compared to the same rats treated with NSC-EV-GABA, MGE-EV-GABA and IN-EV-GABA. 4B. The total time spent in seizures, time spent in stage III, IV and V seizures per 10 h (seconds) in MGE-EV-GABA, NSC-EV-GABA and IN-EV-GABA groups were compared to a group of untreated REs. REs: Rats with epilepsy; MGE-EV-GABA: GABA loaded into EVs derived from medial ganglionic eminence cells; IN-EV-GABA: GABA loaded into EVs derived from interneurons. For multiple comparisons between the groups, Newman-Keuls post hoc test was used. **p < 0.01; *p < 0.05, ns: non-significant