Fig. 6
From: Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
Effect of intranasal administration of GABA-loaded EVs on a novel object recognition test (A) and novelty suppressed feeding test (B). 6 A: The upper panel demonstrates the number of visits to novel and known objects in trial 3 from the group belonging to naïve rats, REs and REs treated with MGE-EV-GABA. The lower panel demonstrates the total time spent with each object in trial 3 from the group of naïve rats, REs and REs treated with MGE-EV-GABA. 6B: This test demonstrates latency to first bite in rats upon 24 h fasting in naïve rats, REs, and REs treated with MGE-EV-GABA. REs: Rats with epilepsy; MGE-EV-GABA: GABA loaded into extracellular vesicles (EVs) derived from medial ganglionic eminence cells; For multiple comparisons between the groups, Newman-Keuls post hoc test was used. **p < 0.01; ***p < 0.001; ns: non-significant