Fig. 7
From: Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
Dual immunostaining of synaptophysin and GABA in the hippocampal dentate hilus of the REs treated with GABA-loaded EVs. Confocal imaging of 0.7 μm Z- section at 630 magnification confirms the co-localization of synaptophysin with GABA in the dentate hilus region. (A) Positive areas for the synaptophysin (red). (B) GABA tagged with o-phthaldialdehyde (green). (C) Co-localization of synaptophysin with GABA (orange). D and E. Inserts from Fig. 7C demonstrating co-localization of synaptophysin and GABA in different areas