From: The potency of mesenchymal stem/stromal cells: does donor sex matter?
MSCs source | Number of Donors | Aspect of differences | Ref. |
---|---|---|---|
Adipose tissue | N/A | Assessing transcriptomic profiles of ASCs derived from male and female donors using TRAM software unveiled donor-sex-related dimorphism, influencing chromosomal segments, some expressed genes, and potency variations. Also, results indicate that female ASCs are likely to differentiate into adipocytes compared to male ASCs. | [38] |
Adipose tissue | M:7 F:7 | Female ASCs exhibit superior immunosuppression potency compared to male ASCs in vitro, as they can consistently suppress PBMC proliferation more effectively. | [51] |
Adipose tissue | M:3 F:3 | Male ASCs have osteogenic differentiation more effectively than female ASCs. | [34] |
umbilical cord | M:6 F:6 | The expression of OCT4 and DNMT1 genes significantly elevated in UC- MSCs isolated from male, as compared to UC-MSCs isolated from female. | [40] |
umbilical cord | M:5 F:5 | Male fetal UC-MSCs displayed a significantly higher proliferation and adipogenic ability than female fetal UC-MSCs. Additionally, male MSCs are more potent in the inflammatory cytokines’ expression to LPS-induced inflammation. | [26] |
Bone Marrow | M:28 F:25 | Female BM-MSCs exhibited a significantly greater ability to suppress T cell proliferation compared to males. BM-MSCs obtained from younger female donors displayed high clonogenic potential, faster division rates, and increased frequency. | [25] |
Bone Marrow | M:7 F:12 | Breast cancer cells proliferate increasingly when MSCs from female donors are involved. | [31] |
Bone Marrow | M:6 F:3 | Female BM-MSCs’ sphingolipidome consisted of 88.35% ceramide, and 10.18% sphingomyelin. On the other hand, male BM-MSCs’ sphingolipidome included 54% ceramide, and 44.53% sphingomyelin. This difference could be associated with different influences on the cell properties. | [60] |
Bone Marrow | M:26 F:32 | BM-MSCs collected from osteoporotic females had more probability to exhibit an enhanced differentiation potency toward adipocytes formation; considered a non-desired differentiation outcome for bone regeneration. | [36] |