From: The potency of mesenchymal stem/stromal cells: does donor sex matter?
MSCs source | Species | Number of Donors | Aspect of differences | Ref. |
---|---|---|---|---|
Bone Marrow | Rat | N/A | The estrogen mitogenic effects were more pronounced in female BM-MSCs, however, combinations of estrogen and dexamethasone is more effective in promoting male BM-MSCs proliferation with different steroid optimal doses and interactions based on donor gender. | [29] |
Bone Marrow | Rat | N/A | Therapeutically, female BM-MSCs have greater efficacy than male MSCs in reducing neonatal hyperoxia-induced lung inflammation and vascular remodeling. The beneficial effects of female MSCs were more pronounced in male animals. | [56] |
Bone Marrow | Rat | N/A | Female BM-MSCs provided a greater protection of myocardial function than their male-derived. The Bcl-xl/Bax ratio is significantly increased after the treatment with BM-MSCs from female donors than their male counterparts | [57] |
Bone Marrow | Rat | M:6 F:6 | Male bone marrow contained significantly higher BM-MSCs than female rats, represented by high CFU numbers in both femora and tibiae | [59] |
Bone Marrow | Mouse | M:4 F:4 | BM-MSCs from female mice have lower osteogenesis than cells from male littermates. | [35] |
Bone marrow | Monkey | M:6 F:6 | Upon differentiation, female BM-MSCs acquire higher neurogenic potential compared with male BM-MSCs. | [33] |
Bone Marrow | pig | M:3 F:3 | Supplementation of beta- estradiol resulted in anti-apoptotic activity up-regulation in only female BM-MSCs, but not in male BM-MSCs. | [30] |
Adipose tissue/ Dermal Skin | Pig | M:3 F:3 | Female ASCs were found to be more resistant to senescence under in vitro culture conditions. | [27] |