Table 2 Risk factors for graft failure [3, 8, 40,41,42]
Immunologic risk factors | Disease/Patient/Donor related | Graft characteristics |
|---|---|---|
HLA disparity between donor and recipient (Haploidentical > MUD & MMD > MSD) | Underlying disease (Non-malignant; Aplastic anemia, Hemoglobinopathies > Malignant) | Graft source (cord blood > bone marrow > mobilized pripheral blood) |
Presence of pre-HSCT donor specific antibodies (DSAs) | Advanced disease in hematologic malignanicies | Low CD34 + cell dose |
Graft manipulation (Ex-vivo T Cell depletion) | Extensive marrow fibrosis; Myelofibrosis | Storage techniques (cryopreservation) |
Intensity of conditioning regimen (RIC > MAC) | Splenomegally (MPD, MDS) | |
Major ABO incompatibility | Extensive pre‐transplantation chemotherapy and/or irradiation | |
History of extensive transfusion | Iron overload | |
Infections (Viral) | Advanced recipient age | |
Graft versus Host Disease (GvHD) | Advanced donor age | |
Post‐transplantation immune suppression regimen | Female donor grafts for male recipients |