Fig. 3
Secretome improved kidney structure following bilateral I/R injury. Representative micrographs of PAS stained sections of outer medulla from sham A, vehicle B and ASC-CS C treated rats are shown 5 days following I/R. Evident tubular damage with abundant cellular debris in the lumen (black arrows), simplified cells lining the basement membrane (red arrow) are frequently observed in vehicle-treated rats B. Minimal tubule debris and a relatively greater degree of hypertrophy was observed regenerating tubules of ASC-CS treated rats (blue arrow); Bar in panel A is 200 µm. D % of severely injured tubules. Data correspond to rats with the greatest degree of initial injury (SCr ≥ 3.0) and are presented as mean ± SEM. *P < 0.05, by Tukey’s multiple comparison test