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Table 1 In vivo outcomes of wound healing augmented by mesenchymal stem cell therapy

From: Mesenchymal stem cell therapy for attenuation of scar formation during wound healing

Experimental details Accelerated wound closure Improved tissue strength Prevented chronic ulceration Improved visual appearance Reference
Murine MSC conditioned medium
Topical delivery
Splinted excisional wounds in mice
    [80]
Allogenic and syngenic murine MSCs
Injection into the wound
Excisional wounds in mice
    [43]
Murine MSCs
Injection into the wound
Excisional wounds in db/db mice
    [116]
Rat ASCs
Injection into the wound
Excisional wounds in diabetic rats
    [117]
Murine MSCs
Injection into the wound margin
Splinted excisional wounds in db/db mice
  [110]
Human MSCs
Injection into wound
Incisional wounds in rabbits
    [118]
Human V53/2 MSC cell line
Seeded on collagen scaffolds
Splinted excisional wounds in mice
   [119]
Human MSCs
Incorporated in fibrin spray
Chronic and acute wounds in humans
  [120]
Swine MSCs
Injection into the wound
Thermal wounds in mini pigs
   [108]
Murine MSCs
Systemic injection
Excisional wounds in mice
    [39]
Rat MSCs
Systemic injection
Excisional wounds in rats
   [121]
  1. ASC, adipose-derived stem cell; MSC, mesenchymal stem cell.