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Table 1 In vivo outcomes of wound healing augmented by mesenchymal stem cell therapy

From: Mesenchymal stem cell therapy for attenuation of scar formation during wound healing

Experimental details Accelerated wound closure Improved tissue strength Prevented chronic ulceration Improved visual appearance Reference
Murine MSC conditioned medium Topical delivery Splinted excisional wounds in mice     [80]
Allogenic and syngenic murine MSCs Injection into the wound Excisional wounds in mice     [43]
Murine MSCs Injection into the wound Excisional wounds in db/db mice     [116]
Rat ASCs Injection into the wound Excisional wounds in diabetic rats     [117]
Murine MSCs Injection into the wound margin Splinted excisional wounds in db/db mice   [110]
Human MSCs Injection into wound Incisional wounds in rabbits     [118]
Human V53/2 MSC cell line Seeded on collagen scaffolds Splinted excisional wounds in mice    [119]
Human MSCs Incorporated in fibrin spray Chronic and acute wounds in humans   [120]
Swine MSCs Injection into the wound Thermal wounds in mini pigs    [108]
Murine MSCs Systemic injection Excisional wounds in mice     [39]
Rat MSCs Systemic injection Excisional wounds in rats    [121]
  1. ASC, adipose-derived stem cell; MSC, mesenchymal stem cell.