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Table 2 Comparison of mesenchymal stem cell cellular therapy with angiogenesis gene therapy in critical limb ischemia

From: Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia

  MSC cellular therapy  
  Autologous MSCs Allogeneic MSCs Angiogenesis gene therapy
Angiogenesis factors Secretion of multiple factors Secretion of multiple factors Specific to the gene
Mode of action Multiple roles: angiogenesis immunomodulation differentiation Multiple roles: angiogenesis immunomodulation differentiation Specific to the gene
Immunogenicity None Yes Yes
Intrinsic limitation Cell-related dysfunction No cell-related dysfunction Gene transfer-related issue
Feasibility as an 'off the shelf' No Yes Yes
Transmission of zoonoses No Unknown Unknown
Predictable pharmacokinetics and pharmacodynamics No No Yes
Cost of production Expensive Expensive Expensive
Requirement for karyotyping Yes Yes No
Mass production No Yes Yes
  1. MSC, mesenchymal stem cell.