Figure 2

Chronic ventricular TNF-α infusion negatively affects SVZ neurogenesis. (A) Schematic showing the experimental setup. (B) Representative confocal maximum intensity projections showing TNF-α effect on EdU⁺ and Dcx⁺ cell numbers in SVZ (control: n = 6; TNF-α: n = 11) and pRMS (control: n = 7; TNF-α: n = 11); dotted line indicates ventricle surface; quantified in (C) and (D). # P ≤0.05 Student's t-test, * P ≤0.05 Mann-Whitney-U-Test, error bars s.e.m.