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Table 1 Frequency of LSK and long-term hematopoietic stem cells at different microenvironments and stages of development

From: Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development

Tissue

% LSK+

% LSK+CD150+CD48-CD41-

FL14.5 (n = 9)

0.45 ± 0.26 *†

0.004 ± 0.004 *

FL17.5 (n = 8)

0.78 ± 0.34 *

0.011 ± 0.006 *

FBM17.5 (n = 6)

1.19 ± 0.57

0.00 ± 0.00 *

Adult BM (n = 11)

2.94 ± 0.70

0.17 ± 0.08

  1. Data shown as mean frequency of live, Lin-/low gated events. The number of independent samples evaluated as n. An asterisk (*) indicates a significant difference (P < 0.05) of LSK or LT-HSCs percentage with adult bone marrow (BM) as reference sample (Tukey and Student's t-test analysis). A dagger (†) indicates a significant difference (P < 0.05) of LSK percentage with FBM17.5 as reference sample (Tukey and Student's t-test analysis). Adult BM, four-week old adult bone marrow; FBM17.5, fetal bone marrow at day 17.5 of gestation; LSK, Lineage- Sca-1+ c-Kit+; LT-HSC, Long Term-Hematopoietic Stem Cells.
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Stem Cell Research & Therapy

ISSN: 1757-6512