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Table 2 Experimental groups

From: Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury

Group

Treatment

Rats, number

Morris water maze-tested, number

Time of sacrifice (number)

Histology, number of rats

Sham injury

No mesenchymal stem cells (MSC)

8

8

1 month (4)

8

    

3 months (4)

 

Sham Injury

Primed MSC

4

Not tested

2 days (4)

4

Traumatic brain injury (TBI)

No MSC

8

8

1 month (4)

8

    

3 months (4)

 

TBI

No MSC

4

Not tested

2 days (4)

4

TBI

Unprimed MSC

8

8

1 month (4)

8

    

3 months (4)

 

TBI

Unprimed MSC

4

Not tested

2 days (4)

4

TBI

Primed MSC

8

8

1 month (4)

8

    

3 months (4)

 

TBI

Primed MSC

4

Not tested

2 days (4)

4

  1. A total of 48 male Sprague-Dawley rats were randomly divided into injury or treatment groups; 12 rats were sham-injured and of these animals, 8 received no stem cell treatment and 4 received RA-primed MSC: 36 rats were subjected to moderate TBI and of these animals 12 were untreated, 12 were treated with unprimed MSC and 12 were treated with RA-primed MSC. Eight animals were randomly selected from each of these groups (sham injury, TBI, TBI with unprimed MSC, TBI treated with primed MSC) for Morris water maze (MWM) evaluation and 4 rats from this and other groups were euthanized for histological evaluations alone.
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Stem Cell Research & Therapy

ISSN: 1757-6512