Skip to main content
Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Figure 4

MSCs generated iTreg cells during the differentiation process of Th1 and Th17 cells. A) Treg generation from Th1 and Th17 cells cocultured with MSCs at different stages of activation and MSC:Th ratios. Treg phenotype was determined according to the percentage of CD4 + CD25+ cells that express Foxp3 by flow cytometry (Dot plot upper A for Th1 and Upper B for Th17). B) Foxp3, Nrp 1 and helios mRNA expression levels weres quantified from Th1 and Th17 cells cocultured in the presence or absence of MSCs at different stage of activation and MSC:Th ratios (** = P <0.01 and * = P <0.05 ). iTreg, induced Treg; MSCs, mesenchymal stem cells; Nrp 1, neuropilin 1; Th, T helper; Treg, regulatory T cells.

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512