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Table 2 Histological and immunohistochemical scoring system used to grade tendon repair in equines

From: Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial

Variable Score and criterion
Shape of tendon cells 1 = Linear (normal)
2 = Slightly oval
3 = Moderately round
4 = Predominantly round
Density of tendon cells 1 = Sparse (normal)
2 = Slightly increased
3 = Moderately increased
4 = Cell layers
Hemorrhage 1 = Absent (normal)
2 = Sparse or uneven
3 = Multiple areas
4 = Predominantly hemorrhagic
Number of vessels 1 = Normal
2 = Slightly increased
3 = Moderately increased
4 = Severely increased
Inflammatory cell infiltrate 1 = Normal
2 = Slightly increased
3 = Moderately increased
4 = Severely increased
Linearity of collagen fibers 1 = Linear
2 = >50% linear
3 = 20% to 50% linear
4 = Absence of linear areas
Uniformity of collagen fibers 1 = Uniformity of the diameter of all fibers
2 = > 50% of the fibers are uniform
3 = 20% to 50% of the fibers are linear
4 = Complete disorder of the fibers
Collagen type III* 1 = < 10% type III
2 = 10% to 50% type III
3 = > 50% a 90% type III
4 = > 90% type III
Factor VIII* 1 = Average labeling of cells, no recognition of the vascular structure
2 = Labeling of a few small vessels
3 = Labeling of several small vessels or greater vessels
4 = Labeling of several great vessels
  1. *Determined from the immunohistochemical analysis.